If you have scanned a file using VirusTotal and the amount of engines that detect it is under 4, then it is extremely likely the file is benign.
Check the engines that detect the file are well known. If they aren’t, then it might be a false positive.
Look up the detection! If it’s a heuristic/artificial intelligence detection, that increases the chance of it being a false positive by quite a lot.
In general, if you are unsure whether the file is malicious or not after going through this post, don’t run it. Better safe than sorry!